CASE REPORT: LONGITUDINAL MONITORING OF CLONAL EVOLUTION BY CIRCULATING TUMOR DNA FOR RESISTANCE TO ANTI-EGFR ANTIBODY IN A CASE OF METASTATIC COLORECTAL CANCER

BackgroundTreatment with anti-EGFR antibody has been shown to prolong survival in patients with RAS wild-type metastatic colorectal cancer (mCRC).However, even patients who initially respond to anti-EGFR antibody therapy, almost without exception, develop resistance to the therapy and then fail to respond.Secondary mutations in the mitogen-activate

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Clotiapine is an atypical antipsychotic indicated for the management of a series of acute psychotic disorders.The current literature lacks evidence concerning the tolerability and clinical use of this drug in the management of individuals with anorexia nervosa (AN).In this study, we report two creme x hello kitty strawberry milk toner cases of adol